Abstract

TORRES, Elza Araújo  and  CARDOSO, Ana Lúcia Peroni Costa. O complexo HLA e doenças. Ciência educ. [online]. 1996, vol.02, pp.77-83. ISSN 1516-7313.

Nearly 530 diseases have been found to be associated to one or more genes in the HLA complex. For many of them, the HLA associations are weak and may be fortuitous. For others, by contrast, these associations are so strong that they are most probably the result of a direct involvement of certain HLA genes in the pathogenesis of the disease. For example, ankylosing spondylitis is strongly associated to B27 and there is strong evidence that the B27 molecule itself represents the genetic predisposition to develop it. Both population and family studies have been used to demonstrate the relationship between marker genes within the HLA complex and various diseases states. The two types of studies yield different types of information. Population studies permit a statistically significant association between a particular HLA marker gene and a particular disease. Family studies provide an opportunity to stablish a cosegregation between a disease susceptibility gene and the HLA complex and may provide evidence for simple dominant or recessive inheritance.

Keywords : HLA Complex; Genes; Diseases; Association; Cosegregation.

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